Vivitrol (Naltrexone) Injection

Vivitrol is the brand name for extended-release naltrexone, an FDA-approved once-monthly intramuscular injection used to treat opioid use disorder and alcohol dependence. Like oral naltrexone, Vivitrol works by blocking opioid receptors in the brain, eliminating the rewarding effects of opioids and reducing cravings for both opioids and alcohol. The key advantage of Vivitrol over oral naltrexone is its monthly dosing schedule. Because the injection is administered by a healthcare provider once every four weeks, it removes the challenge of daily medication adherence, which is one of the most common barriers to successful treatment. The injection is given in the gluteal muscle during a brief office visit. After injection, the medication is released gradually over the following month, maintaining consistent therapeutic levels in the body. Vivitrol is most effective when used as part of a comprehensive treatment program that includes counseling, behavioral therapy, and ongoing medical support. At Spinal Interventions, our addiction medicine providers integrate Vivitrol therapy into individualized treatment plans designed to support long-term recovery.